WinPep®Sparin, a new ingredient approved in IECIC, is a novel peptide inspired by Sphingobacteriumlipoprotein that has a soothing & calming effect.

The peptide is engineered to specifically target the G Protein-coupled Receptor PAR-2, a Neuromodulator, decrease neural sensitivity, relieve aching, itching, and burning. Also anti-inflammatory, it inhibits the activation of PAR2-AKT-NF-κB-proinflammatory cytokines pathway, alleviates skin irritation, and improves redness.