We’re at SCS Formulate 2026!
October 23, 2026PDRN PHYCOPEPTIDE is a second-generation PDRN active by CODIF enriched with 2,434 bioactive phycopeptides, designed for advanced anti-ageing and firming formulations. Traditionally, PDRN is sourced from salmon or rainbow trout, whereas PDRN PHYCOPEPTIDE is derived from Chlorella vulgaris, cultivated in France, making it a vegan alternative.
It combines regenerative PDRN technology with collagen-supporting phycopeptides to deliver visible skin density and tightening benefits. PDRN PHYCOPEPTIDE is COSMOS approved with its key performance claims including activation of growth factors, stimulation of collagen expression across all skin layers, and clinically observed firming effects after 28 days. This active was developed specifically with mature skin, neck, and décolleté applications in mind.
What's New?
New information has emerged on PDRN PHYCOPEPTIDE, revealing a distinctive characteristic of its Chlorella-derived PDRN and providing further insight into its innovative approach to skin regeneration. Unlike conventional PDRN, which typically displays a single DNA profile of approximately 40% AT and 60% GC, Chlorella PDRN contains two complementary DNA populations:
• GC-rich nuclear genome: 35% AT / 65% GC
• AT-rich chloroplast genome: 65% AT / 35% GC
The two DNA populations provide a distinctive composition within the PDRN, while the phycopeptide complex adds a further layer of activity. This combination makes PDRN PHYCOPEPTIDE a unique active complex for advanced skin regeneration and anti-ageing formulations.
Image: Tensor effect observed after 28 days (Source: CODIF)
Why are formulators paying attention?
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Vegan regenerative technology: low molecular weight PDRN (<50kDa) combined with 2,434 phycopeptides to support skin regeneration and collagen pathways.
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Collagen 360° activation: helps reactivate collagen expression in the dermis, dermal–epidermal junction, and epidermis.
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Supports skin density, firmness and collagen quality: in vitro data showed stimulation of multiple fibroblast growth factors (FGF2, FGF5, FGF7, FGF13) and increased collagen-related markers. Testing on human skin explants showed a significant improvement in the extracellular matrix.
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Demonstrated in vivo anti-wrinkle and tensor effects: testing on crow’s feet wrinkles showed a significant improvement i wrinkle depth and skin texture at 1% and 2%, with results already observed after 14 days. After 28 days of use at 2%, skin deformation decreased by an average of 8.4%, with reductions of up to 46% in some volunteers.
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Sustainable biotechnology sourcing: Chlorella cultivated in France using renewable energy and a high recycled-water process.
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Ideal Applications
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Anti-ageing creams and serums
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Neck and décolleté firming treatments
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Eye contour products
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Overnight recovery masks
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Professional and prestige skincare formulations
Ideal Applications
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Recommended use level: 2%
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Solubility: Water Soluble
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Heat stability: Up to 90°C for 4 hours
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INCI: Water (and) Glycerin (and) Pentylene Glycol (and) Chlorella Vulgaris Extract (and) Sodium DNA
If you would like to learn more about PDRN PHYCOPEPTIDE, request a sample, or discuss your formulation requirements, please get in touch with our team. We'd be happy to support your development project.
