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August 6, 2026
ProTec Ingredia Regains EcoVadis Gold
August 18, 2026The conversation around longevity has moved beyond supplements and into skincare, with NAD (Nicotinamide Adenine Dinucleotide) emerging as one of the industry's most exciting active ingredients.
Long established as an oral supplement, NAD is now gaining significant attention in cosmetic formulations. As a naturally occurring coenzyme present in every living cell, NAD is essential for cellular energy production, DNA repair and healthy ageing pathways. However, NAD levels decline significantly with age, contributing to oxidative stress and many of the recognised biological hallmarks of skin ageing.
By supporting cellular repair mechanisms and maintaining healthy NAD levels, formulators can target the underlying processes of skin ageing rather than simply addressing its visible signs. Cetpro® NAD supports multiple biological pathways associated with the recognised hallmarks of ageing, including:
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Genomic Instability – Adequate NAD availability is critical to drive DNA repair enzymes and pathways such as PARP1, SIRT1 and SIRT6.
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Cellular Senescence – Low NAD promotes senescence in skin, whilst restoration of NAD reduces the burden of senescent cells.
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Epigenetic Alterations – NAD-dependent sirtuins are critical for youthful epigenetic regulation. Reduced NAD means sirtuins cannot perform this essential role.
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Mitochondrial Dysfunction – Adequate NAD is critical to healthy mitochondrial function and the removal of damaged mitochondria.
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Telomere Attrition – NAD restoration has been shown to alleviate telomere dysfunction.
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Altered Intracellular Communication – Low NAD promotes age-related inflammation.
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Loss of Proteostasis – NAD is required for SIRT1-mediated activation of autophagy to clear damaged cellular proteins.
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Deregulated Nutrient Sensing – NAD levels are critical for sensing the energetic status of the cell, allowing adaptation to energy stress.
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Stem Cell Exhaustion – NAD restoration has been shown to promote stem cell rejuvenation.
By supporting these fundamental mechanisms of skin ageing, Cetpro® NAD enables formulators to develop next-generation longevity skincare that works beyond surface-level anti-ageing claims.
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